Title: A Subconcussive Load Effect & Trauma Profile for Chronic Traumatic Encephalopathy: A Meta-analysis of New Trends
Authors: P Montenigro, C Cove, M Crowell, C Nowinski, C Cantu, R Stern
Publication Date - 2012
Journal Name: Poster presented at Boston University’s annual Medical Student Summer Research Symposium, Boston, MA
Location: The Center for the Study of Traumatic Encephalopathy, Departments of Neurosurgery and Neurology The Boston University School of Medicine, Boston, MA
Click to enlarge the poster:
This poster received an Honorable Mention in the category of “Clinical Science Posters” for the 2012 **Serchuck Award
Description: Meta-analysis of autopsy confirmed CTE cases to analyze potential differences in symptom onset and time to death between case reports in football players and boxers. This analysis is based on a theoretical framework which suggests exposure difference to brain trauma relate to differences in disease onset and progression. For instance, boxers would be expected to have greater exposure to rotational forces transmitted to the brainstem-cerebellum (lateral chin impacts from a hook punch), whereas football players endure more frequent frontal forehead impacts (see accelerometer literature, impact location, linemen). Considering the vulnerability of the frontal lobes to injury, we hypothesised that football players would have a younger age at symptom onset, and a faster rate of progression than might be expected in boxers. The mean ages of death in CTE cases were 41.9 and 61.0 for football players and boxers, respectively (P<0.0001) supporting this hypothesis. The mean number of years from symptom onset to death was 7.7 and 18.9 for football players and boxers, respectively (P=0.007) supporting this hypothesis. It should be noted, however that the analysis is preliminary and unadjusted. Our results have important implications and do support our original hypothesis. Future longitudinal analysis in living players is required to establish the underlying etiology for the observed results.