Philip H. Montenigro

Chronic traumatic encephalopathy: Historical origins and current perspective

– Posted in: Publications

Annual Review of Clinical Psychology 1

Annual Review of Clinical Psychology

Montenigro PH, Corp DT, Stein T, Cantu RC, Stern RA. “Chronic traumatic encephalopathy: Historical origins and current perspective.” Annual Review of Clinical Psychology 2015, Volume 11, PMID: 25581233. —Impact Factor 12.9

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Abstract:
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is most often identified in postmortem autopsies of individuals exposed to repetitive head impacts, such as boxers and football players. The neuropathology of CTE is characterized by the accumulation of hyperphosphorylated tau protein in a pattern that is unique from that of other neurodegenerative diseases, including Alzheimer’s disease. The clinical features of CTE are often progressive, leading to dramatic changes in mood, behavior, and cognition, frequently resulting in debilitating dementia. In some cases, motor features, including parkinsonism, can also be present. In this review, the historical origins ofCTEare revealed and an overview of the current state of knowledge of CTE is provided, including the neuropathology, clinical features, proposed clinical and pathological diagnostic criteria, potential in vivo biomarkers, known risk factors, and treatment options. Expected final online publication date for the Annual Review of Clinical Psychology Volume 11 is March 28, 2015. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.

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